{"id":26834,"date":"2021-03-14T14:05:29","date_gmt":"2021-03-14T06:05:29","guid":{"rendered":"https:\/\/www.therfiles.com\/?p=26834"},"modified":"2021-11-10T11:48:57","modified_gmt":"2021-11-10T03:48:57","slug":"list-covid-19-vaccines","status":"publish","type":"post","link":"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/","title":{"rendered":"Covid-19 Vaccines &#8211; Type, Safety, Efficacy, Trial Results, Approval, Side Effects"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26834\" class=\"elementor elementor-26834\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d0bf573 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d0bf573\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eac91e0\" data-id=\"eac91e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-550466d elementor-widget elementor-widget-text-editor\" data-id=\"550466d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Here&#8217;s the consolidated information of the various Covid19 Vaccines available that have been approved for emergency use by selected countries. As of 22 June 2021, globally 3,888,361 people have died of COVID-19 (worldometers.info). Vaccines are a critical tool in the battle against COVID-19.<\/p><br \/><h2>Approval for Emergency Use<\/h2><p>Rigorous assessment of late phase clinical trial data are conducted to make sure that vaccines adhere to stringent criteria of safety, efficacy and quality reviewed by experts before they are given the green light for <strong>emergency use<\/strong> approval. The company producing the vaccine must continue to generate more data to enable full approval. <strong>Vaccine efficacy<\/strong> is defined as reduction percentage in disease incidence in a vaccinated group compared to an unvaccinated group under optimal conditions (randomized controlled trial) &#8211; [who.int].<\/p><br \/><p>On top of that, the drug control\/ pharmaceutical authority of each country will evaluate the vaccines before they are approved to be used for their people.<\/p><br \/><h2>Vaccines Type<\/h2><h4><strong>mRNA<\/strong><\/h4><p>The mRNA approach uses a section of genetic material that delivers the instructions to make the protein that our immune system responds to. No actual part of the microbe is used. Before the COVID-19 pandemic, none had yet been through the full approvals process for use in humans. The mRNA Covid-19 vaccines produced by <a href=\"#pfizer\">BioNTech-Pfizer (more info below)<\/a> and <strong>Moderna<\/strong> (<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2035389\" target=\"_blank\" rel=\"noopener\">Phase 3 Results published on nejm.org<\/a>) reported high efficacy rate of more than 90% and minimal side effects. It requires extreme cold storage.<\/p><br \/><h4><strong>Inactivated Vaccine<\/strong><\/h4><p>This approach uses the disease-carrying microbe which has been killed\/ inactivated. These vaccines are being used for a long time and proven safe to work in people. However it is not been proven that Inactivated vaccine such as Sinovac is more effective or safer than the others (like BioNTech or Moderna&#8217;s mRNA). Read <a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/infectious-diseases-expert-david-lye-calls-out-misinformation-about-covid-19\" target=\"_blank\" rel=\"noopener\">Misinformation about Covid Vaccine<\/a>. Available Inactivated Covid-19 Vaccines are:<\/p><ul><li style=\"list-style-type: none;\"><ul><li>China&#8217;s <strong>CoronaVac by Sivovac<\/strong>\u00a0<\/li><li>India&#8217;s <strong>Covaxin by Bharat Biotech<\/strong><\/li><li><strong>Sinopharm (China)<\/strong> Phase three trials: 79% effective. Phase three trial in United Arab Emirates (published on Journal of American Medical Association &#8211; JAMA): 78.1% effective. <a href=\"https:\/\/www.who.int\/news\/item\/07-05-2021-who-lists-additional-covid-19-vaccine-for-emergency-use-and-issues-interim-policy-recommendations\" target=\"_blank\" rel=\"noopener\">Approved by WHO for emergency use<\/a> on 7th May 2021.<\/li><\/ul><\/li><\/ul><br \/><h4><strong>Viral Vector Vaccine<\/strong><\/h4><p>Uses a modified version of a different virus (the vector) to deliver important instructions to our cells to produce the harmless spike protein to trigger the immune system (<a href=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/different-vaccines\/viralvector.html\" target=\"_blank\" rel=\"noopener\">cdc.gov<\/a>). Viral Vector Covid-19 vaccines:<\/p><ul><li style=\"list-style-type: none;\"><ul><li><strong>AstraZeneca\/Oxford<\/strong> (<a href=\"#astra\">Trial Results below<\/a>) has an efficacy of 62-90%.<\/li><li><strong>Janssen (Johnson &amp; Johnson)<\/strong> has an overall efficacy of 66%, 85% effective in preventing severe disease after a single dose (<a href=\"https:\/\/www.jnj.com\/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial#:~:text=Phase%203%20ENSEMBLE%20Study%20Safety%20Data&amp;text=A%20review%20of%20adverse%20events,than%20200%2C000%20people%20to%20date.\" target=\"_blank\" rel=\"noopener\">JnJ Trial Results<\/a>). Approved by <a href=\"https:\/\/www.who.int\/news\/item\/12-03-2021-who-adds-janssen-vaccine-to-list-of-safe-and-effective-emergency-tools-against-covid-19\" target=\"_blank\" rel=\"noopener\">WHO for emergency use<\/a> on 12th Mar 2021.<\/li><li>Russia&#8217;s Viral Vector <strong>Gam-COVID-Vac by Sputnik V<\/strong> Efficacy is at 91.6%.<\/li><li>China&#8217;s single dose <strong>CanSinoBIO<\/strong> has an Efficacy of 65.7%.\u00a0<\/li><\/ul><\/li><\/ul><br \/><h3>Variants (First Detected)<\/h3><ul><li><strong>B.1.1.7<\/strong> also known as the <strong>Alpha<\/strong> variant (UK)<\/li><li><strong>B.1.351<\/strong> also known as <strong>Beta<\/strong> (South Africa Dec 2020)<\/li><li><strong>P.1<\/strong> also known as <strong>Gamma<\/strong> (Brazil)<\/li><li><strong>B.1.617.2<\/strong> strain also known as <strong>Delta<\/strong> variant (India Dec 2020)<\/li><\/ul><br \/><h3>Adverse Reactions<\/h3><p>[source: <a href=\"https:\/\/www.gov.uk\/government\/publications\/coronavirus-covid-19-vaccine-adverse-reactions\/coronavirus-vaccine-summary-of-yellow-card-reporting\" target=\"_blank\" rel=\"noopener\">Medicines &amp; Healthcare Regulatory Agency (MHRA)<\/a>]<\/p><p><span style=\"color: inherit; font-family: inherit; font-weight: inherit;\">Most adverse reaction reports relate to injection-site reactions and generalised symptoms such as a \u2018flu-like\u2019 illness, headache, chills, fatigue, nausea, fever, dizziness, weakness, aching muscles, and rapid heartbeat. Generally, these reactions are not associated with more serious illness and likely reflect an expected, normal immune response to the vaccines. Many of adverse reactions reported do not have any relation to the vaccine and it is often coincidental that they both occurred around the same time. as they would have happened anyway even without vaccine.<\/span><\/p><h4>As of 9 June 2021 in the UK:<\/h4><p>Estimated first doses of vaccine administered and Cases of serious adverse reactions reported by Vaccine<\/p><table style=\"border-collapse: collapse; width: 399.02pt;\" border=\"0\" width=\"798\" cellspacing=\"0\" cellpadding=\"0\"><colgroup> <col style=\"width: 103.00pt;\" width=\"206\" \/> <col style=\"width: 93.00pt;\" width=\"186\" \/> <col style=\"width: 100.00pt;\" width=\"200\" \/> <col style=\"width: 103.00pt;\" width=\"206\" \/> <\/colgroup><tbody><tr style=\"height: 87.00pt;\"><td class=\"et3\" style=\"height: 87.00pt; width: 103.00pt;\" width=\"206\" height=\"174\">Covid-19 Vaccine<\/td><td class=\"et4\" style=\"width: 93.00pt;\" width=\"186\">Estimated first doses of vaccine administered (million doses)<\/td><td class=\"et5\" style=\"width: 100.00pt;\" width=\"200\">Adverse reactions associated with *anaphylaxis or anaphylactoid<\/td><td class=\"et5\" style=\"width: 103.00pt;\" width=\"206\">Major thromboembolic events (blood clots) with concurrent thrombocytopenia (low platelet counts)<\/td><\/tr><tr style=\"height: 24.00pt;\"><td class=\"et3\" style=\"height: 24.00pt;\" height=\"48\">BioNTech\/ Pfizer<\/td><td class=\"et6\">15.6<\/td><td class=\"et7\">376<\/td><td class=\"et7\">\u00a0<\/td><\/tr><tr style=\"height: 27.00pt;\"><td class=\"et3\" style=\"height: 27.00pt;\" height=\"54\">AstraZeneca<\/td><td class=\"et6\">24.6<\/td><td class=\"et7\">740<\/td><td class=\"et7\">390 (0.0016%)<\/td><\/tr><tr style=\"height: 24.00pt;\"><td class=\"et3\" style=\"height: 24.00pt;\" height=\"48\">Moderna<\/td><td class=\"et6\">0.6<\/td><td class=\"et7\">12<\/td><td class=\"et7\">\u00a0<\/td><\/tr><\/tbody><\/table><br \/><p>To compare,\u00a0<a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-updated-information-about-risk-blood-clots-women-taking-birth-control\" target=\"_blank\" rel=\"noopener\">according to FDA Drug Safety Communication:<\/a> the risk of developing a blood clot for women who use birth control pills is 3-9 out of 10,000 women (0.03% &#8211; 0.09%)<\/p><br \/><p>*<strong>Anaphylaxis<\/strong> is a severe, potentially life-threatening allergic reaction that can occur within seconds or minutes of exposure to something you&#8217;re allergic to (mayoclinic)<\/p><p><br \/><br \/><\/p><h2>List of Covid-19 Vaccines\u00a0<\/h2><h3>BNT162b2 (by Pfizer Inc. and BioNTech)<\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-26838\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/pfizer-biontech-logo-300x186.jpg\" alt=\"pfizer biontech logo\" width=\"300\" height=\"186\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/pfizer-biontech-logo-300x186.jpg 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/pfizer-biontech-logo.jpg 559w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>Pfizer Inc. and BioNTech&#8217;s safety and final efficacy results from the pivotal Phase 3 trial of BNT162b2, their mRNA-based COVID-19 vaccine candidate has been <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2034577\" target=\"_blank\" rel=\"noopener\">published on The New England Journal of Medicine<\/a> (nejm.org on 31 Dec 2020). In the trial of 43,448 participants, who were 16 years and older, 21,720 of whom received BNT162b2 and 21,728 placebo, the <strong>two-dose regimen<\/strong> of 30 \u03bcg BNT162b2, which was given 21 days apart, was well-tolerated and demonstrated vaccine <strong>efficacy of 95%<\/strong> against COVID-19. There were 170 cases of COVID-19 observed with onset at least 7 days after the second dose; 8 cases occurred in vaccine recipients, and 162 in placebo recipients. <strong>Trial sites<\/strong> were in the United States, Argentina, Brazil, South Africa, Germany and Turkey. The incidence of <strong>serious adverse events<\/strong> was low and was similar in the vaccine and placebo groups.<\/p><br \/><h4>Efficacy Calculation<\/h4><p><strong>Risk among vaccinated patients<\/strong> = 8\/21720<\/p><p><strong>Risk among unvaccinated patients (placebo)<\/strong> = 162\/21728<\/p><p><strong>Efficacy<\/strong> = 100\u00d7(1\u2212[risk among vaccinated patients\/risk among unvaccinated patients])<\/p><p>= 100*(1-(8\/21720\/(162\/21728))) = 95%<\/p><br \/><h4><a href=\"https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/pfizer\/downloads\/storage-summary.pdf\" target=\"_blank\" rel=\"noopener\">Storage and Handling Summary<\/a><\/h4><p>Recommended Storage Temperature:\u00a0-70\u00b0C (\u00b110\u00b0C)<\/p><p>The vaccine can be stored for five days at refrigerated 2-8\u00b0C conditions.<\/p><br \/><p><strong>Type:<\/strong> mRNA<\/p><p><strong>Interval between 2 doses:<\/strong> 21 days<\/p><p><strong>Country:<\/strong> BioNTech (Germany) and Pfizer (USA)<\/p><p><strong>Approval for children aged 12 to 15:<\/strong> USA (10 th May 2021) | Singapore (18th May 2021) | Hong Kong (3rd June) | UK (4th June 2021)<\/p><p><a href=\"https:\/\/www.who.int\/news\/item\/31-12-2020-who-issues-its-first-emergency-use-validation-for-a-covid-19-vaccine-and-emphasizes-need-for-equitable-global-access\" target=\"_blank\" rel=\"noopener\">Approved for emergency use by WHO:<\/a> 31 Dec 2020<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/6\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 88 countries<\/p><p><strong>Effectiveness against Variants:<\/strong> 88% effective two weeks after the second dose, against the B.1.617.2 (Delta) variant and 93% against B.1.1.7 (Alpha), known as the UK variant (<a href=\"https:\/\/www.bmj.com\/content\/373\/bmj.n1346\" target=\"_blank\" rel=\"noopener\">British Medical Journal &#8211; bmj.com<\/a>)<\/p><br \/><h3>CoronaVac (by Sinovac)<\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-26839\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sinovac-logo-300x56.jpg\" alt=\"sinovac logo\" width=\"300\" height=\"56\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sinovac-logo-300x56.jpg 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sinovac-logo.jpg 561w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>Some 25,000 participants enrolled in Sinovac\u2019s Stage 3 clinical trials, which were conducted in <strong>Brazil, Turkey, Indonesia and Chile<\/strong>. After 14 days following vaccination with 2 doses of vaccine, the efficacy rate against diseases caused by COVID-19 was 50.65% for all cases, 83.70% for cases requiring medical treatment, and 100.00% for hospitalized, severe, and fatal cases (<a href=\"http:\/\/www.sinovac.com\/?optionid=754&amp;auto_id=922\" target=\"_blank\" rel=\"noopener\">sinovac.com<\/a>). Brazil and Turkey evaluated the efficacy of the vaccine in health care workers at higher risk of infections. According to Butantan Institute in Brazil, there have not been any serious adverse effects recorded. Sinovac&#8217;s lower efficacy rate can be due to their evaluation method. For example, Sinovac evaluated asymptomatic and very mild cases, while BioNTech only included symptomatic cases in their trial results.<\/p><h4>Efficacy Rate of Phase 3 Trial in Brazil<\/h4><p><a href=\"https:\/\/brazilian.report\/coronavirus-brazil-live-blog\/2021\/01\/12\/coronavac-has-overall-efficacy-of-50-4-percent-says-butantan\/\" target=\"_blank\" rel=\"noopener\">The Brazilian Report<\/a><\/p><p>78% (Asymptomatic and very mild cases are not included)<br \/>50.4% (Asymptomatic and very mild cases are included)<\/p><h4>Efficacy &#8211; Phase three trials Interim data<\/h4><p>Turkey: 91.25%<br \/>Indonesia: 65.3%<\/p><br \/><p><strong>Storage Temperature:<\/strong>\u00a02-8\u00b0C (Standard Refrigerator)<\/p><p><strong>Type:<\/strong> Inactivated Vaccine<\/p><p><strong>Interval between 2 doses:<\/strong> 14 days<\/p><p><strong>Country:<\/strong> China<\/p><p><a href=\"https:\/\/www.who.int\/news\/item\/01-06-2021-who-validates-sinovac-covid-19-vaccine-for-emergency-use-and-issues-interim-policy-recommendations\" target=\"_blank\" rel=\"noopener\">Approved for emergency use by WHO:<\/a> 1st June 2021<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/7\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 29 countries<\/p><p><br \/><br \/><a name=\"astra\"><\/a><\/p><h3>AstraZeneca-University of Oxford<\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-26840\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/astra-zeneca-oxford-vaccine-logo-300x163.jpg\" alt=\"astra zeneca oxford vaccine logo\" width=\"300\" height=\"163\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/astra-zeneca-oxford-vaccine-logo-300x163.jpg 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/astra-zeneca-oxford-vaccine-logo.jpg 534w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>This vaccine consists of a replication-deficient chimpanzee adenoviral vector, containing the SARS-CoV-2 structural surface glycoprotein antigen (spike protein; nCoV-19) gene. 11,636 participants (<strong>7548 in the UK, 4088 in Brazil<\/strong>) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62\u00b71% and in participants who received a low dose followed by a standard dose, efficacy was 90\u00b70% (<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)32661-1\/fulltext\" target=\"_blank\" rel=\"noopener\">Results published on thelancet.com<\/a>). No serious safety concerns have emerged from the clinical trials.<\/p><br \/><p><strong>Efficacy Rate:<\/strong> 62% &#8211; 90%<\/p><p><strong>Storage Temperature:<\/strong>\u00a02-8\u00b0C (Standard Refrigerator)<\/p><p><strong>Type:<\/strong> Viral Vector Vaccine<\/p><p><strong>Interval between 2 doses:<\/strong> 28 days &#8211; 12 weeks<\/p><p><strong>Country:<\/strong> AstraZeneca (Sweden) and Oxford (British)<\/p><p><a href=\"https:\/\/www.who.int\/news\/item\/15-02-2021-who-lists-two-additional-covid-19-vaccines-for-emergency-use-and-covax-roll-out\" target=\"_blank\" rel=\"noopener\">Approved for emergency use by WHO:<\/a> 15 Feb 2021<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/4\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 110 countries<\/p><p><strong>Effectiveness against Variants:<\/strong> 60% effective against B.1.617.2 (Delta) at two weeks after the second dose and 66% against the Alpha (UK) variant (<a href=\"https:\/\/www.bmj.com\/content\/373\/bmj.n1346\" target=\"_blank\" rel=\"noopener\">British Medical Journal &#8211; bmj.com<\/a>).<\/p><br \/><h3><strong>Moderna<\/strong><\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-29978\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/06\/moderna-logo-300x76.png\" alt=\"moderna-logo\" width=\"300\" height=\"76\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/06\/moderna-logo-300x76.png 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/06\/moderna-logo.png 539w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>(<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2035389\" target=\"_blank\" rel=\"noopener\">Phase 3 Results published on nejm.org<\/a>)<\/p><p>The mRNA-1273 vaccine is a lipid nanoparticle\u2013encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.<\/p><h4>Phase 3 randomized, observer-blinded, placebo-controlled trial\u00a0<\/h4><p>The trial enrolled 30,420 volunteers across the <strong>United States<\/strong>, half (15,210 individuals) were randomly assigned to receive vaccine and the other half the placebo. Symptomatic Covid-19 illness was confirmed in 185 participants in the placebo group and in 11 participants in the mRNA-1273 group. The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease. Moderate, transient reactogenicity (short-term common unfavorable reactions) after vaccination occurred more frequently in the mRNA-1273 group. Serious adverse events were rare, and the incidence was similar in the two groups.<\/p><p><strong>Efficacy Rate:<\/strong> 94.1%<\/p><p><strong>Storage Temperature:<\/strong> <span id=\"page294R_mcid38\" class=\"markedContent\"><span dir=\"ltr\">50\u00b0C and -15\u00b0C\u00a0<\/span><\/span><\/p><p><span id=\"page1R_mcid171\" class=\"markedContent\"><span dir=\"ltr\">Unpunctured vials<\/span><\/span><span id=\"page1R_mcid172\" class=\"markedContent\"><span dir=\"ltr\"> may be stored in the refrigerator between <\/span><\/span><span id=\"page1R_mcid173\" class=\"markedContent\"><span dir=\"ltr\">2\u00b0 to 8\u00b0C (36\u00b0 to 46\u00b0F) for up to 30 days.<\/span><\/span><span id=\"page1R_mcid174\" class=\"markedContent\"><\/span><\/p><p><strong>Type:<\/strong> mRNA<\/p><p><strong>Interval between 2 doses:<\/strong> 28 days apart<\/p><p><strong>Country:<\/strong> USA<\/p><p><a href=\"https:\/\/www.who.int\/news\/item\/30-04-2021-who-lists-moderna-vaccine-for-emergency-use\" target=\"_blank\" rel=\"noopener\">WHO lists Moderna vaccine for emergency use:<\/a>\u00a0 30 April 2021<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/22\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 53 countries<\/p><br \/><h3>Gam-COVID-Vac\/\u00a0Gamaleya\u00a0by Sputnik V<\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-26856\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sputnik-v-covid-vaccine-russia-300x104.jpg\" alt=\"sputnik v covid vaccine russia\" width=\"300\" height=\"104\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sputnik-v-covid-vaccine-russia-300x104.jpg 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/sputnik-v-covid-vaccine-russia.jpg 426w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>The efficacy rate of the adenoviral vector-based COVID-19 vaccine Gam-COVID-Vac in a randomised, double-blind placebo-controlled multicentre phase 3 trial in Moscow, Russia, including 21,862 participants, with a 21-day interval between the first dose and the second dose is 91.6%.<\/p><br \/><p>45 (0\u00b73%) of 16,427 participants in the vaccine group and 23 (0\u00b74%) of 5,435 participants in the placebo group had serious adverse events; none were considered associated with vaccination, with confirmation from the independent data monitoring committee. Four deaths were reported during the study (three [&lt;0\u00b71%] of participants in the vaccine group and one [&lt;0\u00b71%] of participants in the placebo group), none of which were considered related to the vaccine (<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00234-8\/fulltext\" target=\"_blank\" rel=\"noopener\">thelancet.com<\/a>).<\/p><p><strong>Efficacy Rate:<\/strong> 91\u00b76%<\/p><p><strong>Storage Temperature:<\/strong> The vaccine is stored and distributed at \u201318\u00b0C, storage at 2\u20138\u00b0C (Standard Refrigerator)<\/p><p><strong>Type:<\/strong> Viral Vector Vaccine<\/p><p><strong>Interval between 2 doses:<\/strong> 21 days<\/p><p><strong>Country:<\/strong> Russia<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/12\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 68 countries<\/p><br \/><h3>Ad5-nCoV by CanSinoBIO<\/h3><p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-26866\" src=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/cansinobio-vaccine-covid-300x80.jpg\" alt=\"cansinobio vaccine covid\" width=\"300\" height=\"80\" srcset=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/cansinobio-vaccine-covid-300x80.jpg 300w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/cansinobio-vaccine-covid-600x160.jpg 600w, https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/03\/cansinobio-vaccine-covid.jpg 704w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p><p>CanSino Biologics Inc\u2019s (CanSinoBIO) COVID-19 vaccine showed 65.7% efficacy in preventing symptomatic cases and a 90.98% success rate in stopping severe disease in an interim analysis of global trials. The CanSinoBIO vaccine is being tested in Pakistan, Mexico, Russia, Argentina and Chile, according to clinical trial registration data. The efficacy of the shot is based on analysis of 30,000 participants and 101 confirmed cases of COVID-19. No serious safety concerns have been raised in the study (<a href=\"https:\/\/www.reuters.com\/article\/us-health-coronavirus-vaccine-pakistan-idUSKBN2A81N0\" target=\"_blank\" rel=\"noopener\">Source<\/a>)<\/p><p><strong>Efficacy Rate:<\/strong> 65\u00b77%<\/p><p><strong>Storage Temperature:<\/strong> 2\u20138\u00b0C (Standard Refrigerator)<\/p><p><strong>Type:<\/strong> Viral Vector Vaccine<\/p><p><strong>Number of doses:<\/strong> 1 dose<\/p><p><strong>Country:<\/strong> China<\/p><p><a href=\"https:\/\/covid19.trackvaccines.org\/vaccines\/2\/\" target=\"_blank\" rel=\"noopener\">Approvals and other Trials:<\/a> Approved in 5 countries<\/p><br \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Here&#8217;s the consolidated information of the various Covid19 Vaccines available that have been approved for emergency use by selected countries. As of 22 June 2021, globally 3,888,361 people have died of COVID-19 (worldometers.info). Vaccines are a critical tool in the battle against COVID-19. Approval for Emergency Use Rigorous assessment of late phase clinical trial data [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":26479,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[435,431,477],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Covid-19 Vaccines - Type, Safety, Efficacy, Trial Results, Approval, Side Effects - The Research Files<\/title>\n<meta name=\"description\" content=\"What are the Covid19 Vaccines Trial Results Efficacy, approval, variants and Actual Adverse Effects since the start of vaccination\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Covid-19 Vaccines - Type, Safety, Efficacy, Trial Results, Approval, Side Effects - The Research Files\" \/>\n<meta property=\"og:description\" content=\"What are the Covid19 Vaccines Trial Results Efficacy, approval, variants and Actual Adverse Effects since the start of vaccination\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/\" \/>\n<meta property=\"og:site_name\" content=\"The Research Files\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-14T06:05:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-11-10T03:48:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.therfiles.com\/wp-content\/uploads\/2021\/02\/vaccine-covid-19.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1044\" \/>\n\t<meta property=\"og:image:height\" content=\"502\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/\",\"url\":\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/\",\"name\":\"Covid-19 Vaccines - Type, Safety, Efficacy, Trial Results, Approval, Side Effects - The Research Files\",\"isPartOf\":{\"@id\":\"https:\/\/www.therfiles.com\/#website\"},\"datePublished\":\"2021-03-14T06:05:29+00:00\",\"dateModified\":\"2021-11-10T03:48:57+00:00\",\"author\":{\"@id\":\"https:\/\/www.therfiles.com\/#\/schema\/person\/30643e5a75d38f5be4fb5630b36d2d0b\"},\"description\":\"What are the Covid19 Vaccines Trial Results Efficacy, approval, variants and Actual Adverse Effects since the start of vaccination\",\"breadcrumb\":{\"@id\":\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.therfiles.com\/list-covid-19-vaccines\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.therfiles.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Covid-19 Vaccines &#8211; 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